What is Mycosis Fungoides (MF)? | POTELIGEO® (mogamulizumab-kpkc)

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MF is the most common form of CTCL

MF generally affects the skin with symptoms such as rash, itchy skin, skin lesions (changes in skin color or texture), or tumors
Research shows that most people with MF live with skin-only symptoms and have a normal life span
In about 1 in 3 people with MF, cancerous T cells may spread within skin and to other parts of the body, including the blood, lymph nodes, and other organs

Image of MF patch

Image of MF plaque

Blood involvement in MF

For some people with MF, cancerous T cells may be in or spread to the blood
- You may hear your doctor call this “blood involvement”
The number of cancerous T cells in your blood may increase if your disease worsens or if your current treatment is not right for you
The more cancerous T cells you have in your blood, the more serious your MF may be

A blood test can measure the amount of cancerous T cells in
the blood

It is possible your doctor gave you a blood test as part of your MF diagnosis
- This is often a flow cytometry test
A flow cytometry test can help identify and measure the amount of cancerous T cells in your blood, if any are present
Your doctor can also give you this test to see if the number of cancerous T cells has increased or decreased by comparing your current results to past results

Stay ahead of your MF. Talk to your doctor about receiving a blood test if you experience any new or worsening symptoms

Jeff’s journey with MF

^“It’s easy to feel overwhelmed and give up. I’m grateful to my clinical care team, family, and friends for helping me to see a path forward, that there was hope.”

See Jeff’s full story

When cancerous T cells progress in the blood, you may need a treatment that can work in both the blood and
the skin

See if POTELIGEO may be right for you

What is POTELIGEO^®
(mogamulizumab-kpkc)?

POTELIGEO is a prescription medicine used to treat mycosis fungoides (MF) or Sézary syndrome (SS) in adults who have tried at least one prior medicine (taken by mouth or injection) that did not work or in whom the disease has come back.

Important Safety Information

What is the most important information I should know about POTELIGEO?

POTELIGEO may cause serious side effects that can be severe or life-threatening including skin problems, infusion reactions, infections, autoimmune problems, and complications from stem cell transplant.

Call or see your healthcare provider right away if you develop any symptoms of the following problems or if these symptoms get worse:

Skin problems: Signs and symptoms of skin reactions may include skin pain, itching, skin blistering or peeling, rash, painful sores or ulcers in your mouth, nose, throat or genital area.
Infusion reactions: Signs and symptoms of infusion reactions may include chills or shaking, redness on your face (flushing), itching or rash, shortness of breath, coughing or wheezing, dizziness, feeling like passing out, tiredness, fever.
Infections: Signs and symptoms of infection may include fever, sweats or chills, nausea, flu-like symptoms, sore throat or difficulty swallowing, shortness of breath, diarrhea or stomach pain, cough.
Autoimmune problems: Some people receiving POTELIGEO may develop autoimmune problems, and some people who already have an autoimmune disease may get worse during treatment with POTELIGEO.
Complications of stem cell transplant: Patients who receive a stem cell transplant using donor stem cells (allogeneic) after treatment with POTELIGEO may experience complications that can be severe and lead to death. Your healthcare provider will monitor you for signs of complications if you have an allogeneic stem cell transplant.

What are the most common side effects of POTELIGEO?

The most common side effects of POTELIGEO include rash, tiredness, diarrhea, muscle and bone pain, and upper respiratory tract infection.

Before starting POTELIGEO treatment, tell your doctor about all your medical conditions, including whether you:

have had a severe skin reaction after receiving POTELIGEO
have had an infusion reaction during or after receiving POTELIGEO
have or have had liver problems including hepatitis B (HBV) infection
have a history of autoimmune problems
have undergone or plan to have a stem cell transplant, using cells from a donor
have lung or breathing problems
are pregnant or plan to become pregnant
- It is not known if POTELIGEO will harm your unborn baby
are breastfeeding or plan to breastfeed
- Talk to your healthcare provider about the best way to feed your baby during treatment with POTELIGEO

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at 1-844-768-3544 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information as well as Patient Information.

What is POTELIGEO^®
(mogamulizumab-kpkc)?

POTELIGEO is a prescription medicine used to treat mycosis fungoides (MF) or Sézary syndrome (SS) in adults who have tried at least one prior medicine (taken by mouth or injection) that did not work or in whom the disease has come back.

Important Safety Information

What is the most important information I should know about POTELIGEO?

POTELIGEO may cause serious side effects that can be severe or life-threatening including skin problems, infusion reactions, infections, autoimmune problems, and complications from stem cell transplant.

Call or see your healthcare provider right away if you develop any symptoms of the following problems or if these symptoms get worse:

Skin problems: Signs and symptoms of skin reactions may include skin pain, itching, skin blistering or peeling, rash, painful sores or ulcers in your mouth, nose, throat or genital area.
Infusion reactions: Signs and symptoms of infusion reactions may include chills or shaking, redness on your face (flushing), itching or rash, shortness of breath, coughing or wheezing, dizziness, feeling like passing out, tiredness, fever.
Infections: Signs and symptoms of infection may include fever, sweats or chills, nausea, flu-like symptoms, sore throat or difficulty swallowing, shortness of breath, diarrhea or stomach pain, cough.
Autoimmune problems: Some people receiving POTELIGEO may develop autoimmune problems, and some people who already have an autoimmune disease may get worse during treatment with POTELIGEO.
Complications of stem cell transplant: Patients who receive a stem cell transplant using donor stem cells (allogeneic) after treatment with POTELIGEO may experience complications that can be severe and lead to death. Your healthcare provider will monitor you for signs of complications if you have an allogeneic stem cell transplant.

What are the most common side effects of POTELIGEO?

The most common side effects of POTELIGEO include rash, tiredness, diarrhea, muscle and bone pain, and upper respiratory tract infection.

Before starting POTELIGEO treatment, tell your doctor about all your medical conditions, including whether you:

have had a severe skin reaction after receiving POTELIGEO
have had an infusion reaction during or after receiving POTELIGEO
have or have had liver problems including hepatitis B (HBV) infection
have a history of autoimmune problems
have undergone or plan to have a stem cell transplant, using cells from a donor
have lung or breathing problems
are pregnant or plan to become pregnant
- It is not known if POTELIGEO will harm your unborn baby
are breastfeeding or plan to breastfeed
- Talk to your healthcare provider about the best way to feed your baby during treatment with POTELIGEO

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at 1-844-768-3544 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information as well as Patient Information.